As a hallmark of aging, cellular senescence, an essentially irreversible cell cycle arrest with apoptosis resistance and a secretory phenotype, manifests across skin layers by affecting epidermal and dermal cells. Knowledge of skin-specific senescent cells, such as melanocytes (epidermal aging) and fibroblasts (dermal aging), will promote our understanding of age-related skin changes and how to optimize patient outcomes in esthetic procedures.
This review provides an overview of skin aging in the context of cellular senescence and discusses senolytic intervention strategies to selectively target skin senescent cells that contribute to premature skin aging.
The Latin America skincare products market is experiencing a paradigm shift, with consumers placing greater…
While people discuss self-love or vanity, in the clandestine operating rooms of Latin America hundreds…
The labelling of personal care products, cosmetics and perfumes in Brazil follows specific Anvisa regulations,…