New Models of Skin Barrier Alteration by Syntivia

5 April 2023

Syntivia has developed two new ex vivo human skin models with altered skin barrier and dehydration.

Those skin models are ideal for demonstrating claims of tissue regeneration, skin barrier reconstruction and hydration to identify new efficient active compounds and cosmetic formulations.

SKIN BARRIER ALTERATION AND RECOVERY

Skin explants obtained by plastic surgery are stripped or exposed to a detergent. The skin explants are then kept alive to allow treatment with cosmetic or dermatological formulations.

After alteration of the skin barrier, several crucial markers of differentiation are decreased while TEWL increases.

After several days, the untreated skin shows a very immature stratum corneum that contains parakeratosis. In contrast, treatment with the test product result in reconstruction of the upper layers of the epidermis and reactivation of the expression of essential markers of the stratum corneum.

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